Keywords: Wound healing Rat Skin Vitamin K MEBO. PDGF, and enhanced fibroblast proliferation and neovascularization of tissues.
Were obtained fromTGFβ and PDGF data in which MK group showed a significant increaseĬonclusion: The wound healing process is supposed to be due to an increase of TGFβ, (99%) was obtained by the MK treated rats compared to the control group. Results: Data presented in our study showed that the best wound contraction percentage Transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF).
The duration of theĮxperiments was as 7, 14, and 21 days post wound surgery.The percentage of woundĬontraction was measured, and the blood serum was collected to test the level of Spray +vitamin K Group, and Group N received no- treatment. Group MK received Mebo ointment+vitamin K injection.Group CK received Cica silver Mebo ointment, Group Creceived Cica silver spray, Group K received Vitamin K injection, Methods: Six groups of albino rats were used (6 rats in each group). Ointment (MEBO) and the Cica silver spray to test their combination with vitamin K Present study was to test the wound healing effect of vitamin K and some common woundĭressing agents available in Erbil city clinical settings such the moist exposed burn A popular application of vitamin K hasīeen used to help in the extravascular removal of blood from the skin. In the coagulation pathways of living organisms. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.īackground and objective: Vitamin K is a fat-soluble vitamin that plays an important role Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments.Ĭonclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non- immunocompromised counterparts. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Wounds were grossly evaluated once a day for signs of inflammation or infection. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. You may report side effects to Health Canada at 1-86.Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. You may report side effects to FDA at 1-80 or at In Canada - Call your doctor for medical advice about side effects. In the US - Call your doctor for medical advice about side effects. If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/ tongue/throat), severe dizziness, trouble breathing. Tell your doctor right away if you have any serious side effects, including: darkening/lightening of the skin, small red dots on the skin.Ī very serious allergic reaction to this drug is rare. Many people using this medication do not have serious side effects. If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Stinging, burning, and redness may occur.